Annulate lamellae and intracellular pathogens

نویسندگان

چکیده

Annulate lamellae (AL) have been observed many times over the years on electron micrographs of rapidly dividing cells, but little is known about these unusual organelles consisting stacked sheets endoplasmic reticulum-derived membranes with nuclear pore complexes (NPCs). Evidence growing for a role AL in viral infection. early life cycles hepatitis C virus (HCV) and, more recently, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), suggesting specific induction mechanisms potentially useful to pathogens. Like other positive-strand RNA viruses, viruses induce host cells rearrangements. The NPCs could mediate exchanges between partially sealed compartments and cytoplasm. may also be involved regulating Ca2+ homeostasis or cell cycle control. They were recently infected Theileria annulata, an intracellular protozoan parasite inducing proliferation. Further studies are required clarify their pathogen/host-cell interactions.

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ژورنال

عنوان ژورنال: Cellular Microbiology

سال: 2021

ISSN: ['1462-5814', '1462-5822']

DOI: https://doi.org/10.1111/cmi.13328